Lecture15 - 1 Carbohydrate & Lipid Structure...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 1 Carbohydrate & Lipid Structure BIOCHEM 227 FALL 2010 Lecture 15 Monday, October 4, 2010 TODAY Revisiting the enzyme design paper Carbohydrates Lipids BCH 227 FALL 2010 LECTURE 15: CARBOHYDRATE & LIPID STRUCTURES 4 OCT 2010 2 Nature 453 : 190 (2008) BCH 227 FALL 2010 LECTURE 15: CARBOHYDRATE & LIPID STRUCTURES 4 OCT 2010 3 Result: functional catalysts for both designs Activity confirmed by assays Structure confirmed by crystallography Enzyme Design Example Comparison of design (grey) and actual (cyan): Enzyme Design Example BCH 227 FALL 2010 LECTURE 15: CARBOHYDRATE & LIPID STRUCTURES 4 OCT 2010 4 Carbohydrates BCH 227 FALL 2010 LECTURE 15: CARBOHYDRATE & LIPID STRUCTURES 4 OCT 2010 5 What is a Carbohydrate? Sugar or starch carbon chain with hydroxyls and carbonyls carbo = carbon chain hydrate = hydrated with added water often follow (CH 2 O) n monosaccharide, disaccharide, polysaccharide Carbohydrates are Energy-Rich Many OH groups that can be oxidized Oxidation is how (most of) life harvests energy from chemicals BCH 227 FALL 2010 LECTURE 15: CARBOHYDRATE & LIPID STRUCTURES 4 OCT 2010 6 What is a Monosaccharide? a simple sugar chain of 3-7 carbons with a ketone or aldehyde at one carbon and one OH each at all others carbons ketone ketose aldehyde aldose also named by number of carbons triose , tetrose, pentose, hexose, heptose Some Monosaccharides BCH 227 FALL 2010 LECTURE 15: CARBOHYDRATE & LIPID STRUCTURES 4 OCT 2010 7 Some Monosaccharides Monosaccharide Stereochemistry trioses have one chiral center the two stereoisomers are named d- and l- normally d-, but some l- BCH 227 FALL 2010 LECTURE 15: CARBOHYDRATE & LIPID STRUCTURES 4 OCT 2010 8 Monosaccharide Stereochemistry For >3 carbons, there are multiple chiral...
View Full Document

Page1 / 29

Lecture15 - 1 Carbohydrate & Lipid Structure...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online