Lecture19 - BCH 227 FALL 2010 LECTURE 19: GLUCONEOGENESIS...

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1 Gluconeogenesis The Pentose Phosphate Pathway BIOCHEM 227 FALL 2010 Lecture 19 Friday, October 15, 2010 TODAY •En e rgy and ATP • Continued: glycolysis • Gluconeogenesis • The pentose phosphate pathway
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2 Energy and ATP Cytoplasm 1000 -57 10 -5 Mitochondrial matrix 10 -46 10 -3 Standard conditions 0.01 -28 1 0.00001 -11 10 3 Equilibrium 0.0000001 0 10 5 Condition [ATP]/[ADP] Δ G Q Nicholls, D.G. and Ferguson, S.J. Bioenergetics . San Diego: Academic Press, 2002. 3 rd ed., pg. 37 Glycolysis – Step 6 Oxidizes G-3-P and generates NADH Produces an anhydride – low stability – sets up for next step Energetically coupled to next step BCH 227 FALL 2010 LECTURE 19: 15 OCT 2010
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3 Glycolysis – Step 6 Glycolysis – Step 7 Cleavage of anhydride and formation of ATP Energy to spare drives this forward and pulls previous reaction BCH 227 FALL 2010 LECTURE 19: 15 OCT 2010
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4 Glycolysis – Step 8 Phosphate is moved from C-3 to C-2 Glycolysis – Step 8 BCH 227 FALL 2010 LECTURE 19: 15 OCT 2010
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5 Glycolysis – Step 9 Dehydration does not release much energy However, this greatly destabilizes the molecule (the enol is unstable) Effectively shifts free energy into the phosphate bond Glycolysis – Step 10 Production of another ATP BCH 227 FALL 2010 LECTURE 19: 15 OCT 2010
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6 Glycolysis in Heart Muscle -13.9 -23.0 pyruvate kinase 10 -2.4 -3.2 enolase 9 -0.6 +4.7 phosphoglycerate mutase 8 -1.1 -16.7 glyceraldehyde-3-phosophate dehydrogenase + phosphoglycerate kinase 6 + 7 negative +7.9 triose phosphate isomerase 5 -5.9 +22.8 aldolase 4 -25.9 -17.2 phosphofructokinase
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Lecture19 - BCH 227 FALL 2010 LECTURE 19: GLUCONEOGENESIS...

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