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Lecture21 - BCH 227 FALL 2010 LECTURE 21 KREBS CYCLE 20 OCT...

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1 The Krebs Cycle (TCA or Citric Acid Cycle) BIOCHEM 227 FALL 2010 Lecture 21 Wednesday, October 20, 2010 TODAY • Conversion of pyruvate to acetyl-CoA •Th e K r eb
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2 Catabolism Pyruvate → Acetyl-CoA Middle carbon is oxidized to a thioester, energy/ e - to NADH Some energy stored in the S-CoA bond COO - on the end is released as CO 2 BCH 227 FALL 2010 LECTURE 21: KREBS CYCLE 20 OCT 2010
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3 Coenzyme-A (CoA) Thiamine Pyrophosphate Thiazolium is an electron sink H is easily removed to give carbanion nucleophile BCH 227 FALL 2010 LECTURE 21: KREBS CYCLE 20 OCT 2010
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4 Lipoic Acid Pyruvate → Acetyl-CoA BCH 227 FALL 2010 LECTURE 21: KREBS CYCLE 20 OCT 2010
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5 Decarboxylation Walsh, C. Enzymatic Reaction Mechanisms . New York: W.H. Freeman, 1979. Oxidation of C-2 Walsh, C. Enzymatic Reaction Mechanisms . New York: W.H. Freeman, 1979. BCH 227 FALL 2010 LECTURE 21: KREBS CYCLE 20 OCT 2010
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6 Pyruvate Dehydrogenase “Substrate Channeling” • Large enzyme complex – Subunits have different catalytic activities • Substrate is channeled between subunits – Never diffuses away – Speeds things up •M any ex amp l e s
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7 The Krebs Cycle The Krebs Cycle •N am ed fo r H an s
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Lecture21 - BCH 227 FALL 2010 LECTURE 21 KREBS CYCLE 20 OCT...

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