Lecture22 - BCH 227 FALL 2010 LECTURE 22: KREBS CYCLE...

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1 The Krebs Cycle (TCA or Citric Acid Cycle) BIOCHEM 227 FALL 2010 Lecture 22 Friday, October 22, 2010 TODAY • Continued: The Krebs Cycle BCH 227 FALL 2010 LECTURE 22: KREBS CYCLE CONTINUED 22 OCT 2010
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2 Krebs Cycle – Step 1 Acetate: 1 C completely oxidized, 1 C completely unoxidized Oxaloacetate: 2 to go) Energetically favorable – thioester provides energy for formation Citrate: 3 COO - , 3 carbon backbone, 1 OH in middle BCH 227 FALL 2010 LECTURE 22: KREBS CYCLE CONTINUED 22 OCT 2010
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3 Oxidation? No! The ketone of oxaloacetate is reduced to an alcohol, but The methyl of acetate is oxidized to a methylene, thus… There is no net redox chemistry here. BCH 227 FALL 2010 LECTURE 22: KREBS CYCLE CONTINUED 22 OCT 2010
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4 Krebs Cycle – Step 2 Moves the OH from middle (Y) to one end (Z) Alkene intermediate Pulled forward by following steps Citrate Isn’t Symmetric • It looks symmetric • But actually is prochiral – Enzymes can distinguish prochiral molecules BCH 227 FALL 2010 LECTURE 22: KREBS CYCLE CONTINUED 22 OCT 2010
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Lecture22 - BCH 227 FALL 2010 LECTURE 22: KREBS CYCLE...

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