Lecture24 - BCH 227 FALL 2010 LECTURE 24 OXIDATIVE...

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1 Oxidative Phosphorylation BIOCHEM 227 FALL 2010 Lecture 24 Wednesday, October 27, 2010 TODAY • Continued: Oxidative phosphorylation –E lectron transport – The [H + ] gradient – ATP synthesis BCH 227 FALL 2010 LECTURE 24:
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2 Electron Transport Chain Complex I 42 polypeptide chains! BCH 227 FALL 2010 LECTURE 24: OXIDATIVE PHOSPHORYLATION CONT. 27 OCT 2010
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3 Complex I Efremov, R.G. et al. Nature 465 : 441-445 (2010) Complex I Efremov, R.G. et al. Nature 465 : 441-445 (2010) BCH 227 FALL 2010 LECTURE 24: OXIDATIVE PHOSPHORYLATION CONT. 27 OCT 2010
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4 Complex II • Succinate dehydrogenase – Krebs Cycle: succinate → fumarate –Four subun its • Electrons taken from succinate to FAD – Passed through three Fe-S centers – Then reduces Q to QH 2 • Doesn’t pump any H + • Heme b: Catches stray e - ? Complex II BCH 227 FALL 2010 LECTURE 24:
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5 Complex III • Homodimer, each with 11 domains • Four hemes and one Fe-S center •Mov e s 4 H +
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This note was uploaded on 12/19/2010 for the course BIOCHEM 227 taught by Professor Coggins during the Fall '10 term at Duke.

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Lecture24 - BCH 227 FALL 2010 LECTURE 24 OXIDATIVE...

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