Lecture26 - BCH 227 FALL 2010 LECTURE 26 ENGINEERING OF...

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1 The Engineering of Biochemical Pathways BIOCHEM 227 FALL 2010 Lecture 26 Monday, November 1, 2010 TODAY • Metabolic pathway engineering – artemisinin (malaria) – taxol (cancer) BCH 227 FALL 2010 LECTURE 26: ENGINEERING OF BIOCHEMICAL PATHWAYS 1 NOV 2010
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2 Metabolic Pathway Engineering • Reengineer microorganisms to synthesize materials that humans need – Use genetics to modify the biochemistry of the bugs – Greater efficiency = lower cost Biosynthesis of Commercial Products • Has been done for some time – Yeast and wine/beer (using natural pathway) • In the genetic era, engineering has been used… – Laboratory overexpression of proteins – Production of protein drugs – Production of commercial enzymes BCH 227 FALL 2010 LECTURE 26: ENGINEERING OF BIOCHEMICAL PATHWAYS 1 NOV 2010
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3 Engineering of Pathways • Introduction of complete pathways for small molecule biosynthesis – moved from another organism? – assembled from multiple pieces? • May require modification of core metabolic pathways – must control precursors – must avoid wasteful side-products Artemisinin • From the plant Artemesia annua (sweet wormwood) • Used in traditional Chinese medicine (qīnghāosù 青蒿素 ) • Treatment for malaria – No resistance (yet) – Should be used in combo therapy •D i t e rp
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This note was uploaded on 12/19/2010 for the course BIOCHEM 227 taught by Professor Coggins during the Fall '10 term at Duke.

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Lecture26 - BCH 227 FALL 2010 LECTURE 26 ENGINEERING OF...

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