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Lecture28 - BCH 227 FALL 2010 LECTURE 28 OXIDATION OF FAT 8...

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1 Oxidation of Fat BIOCHEM 227 FALL 2010 Lecture 28 Monday, November 8, 2010 TODAY • Normal Oxidation of Fat – Glycerol Oxidation – β Oxidation of Saturated Fatty Acids – β Oxidation of Unsaturated Fatty Acids – β Oxidation for Odd Numbers of Carbons BCH 227 FALL 2010 LECTURE 28: OXIDATION OF FAT 8 NOV 2010
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2 Catabolism Triglycerides • Esters of fatty acids with glycerol BCH 227 FALL 2010 LECTURE 28: OXIDATION OF FAT 8 NOV 2010
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3 Fatty Acids Triglycerides •C l e av ed by lipases – Makes glycerol + 3 free fatty acids • Parts are oxidized – Highly reduced = High energy content
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4 Glycerol Oxidation – Step 1 Activation of one carbon of glycerol by adding a phosphate. Glycerol Oxidation – Step 2 Oxidation of middle carbon to a ketone Product DHAP enters glycolysis directly BCH 227 FALL 2010 LECTURE 28: OXIDATION OF FAT 8 NOV 2010
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5 Glycerol Oxidation Fatty Acid Oxidation • Oxidized in the mitochondria • Must be activated – Attachment of CoA • Must be imported into the mitochondrion – Carnitine Shuttle BCH 227 FALL 2010 LECTURE 28: OXIDATION OF FAT 8 NOV 2010
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Fatty Acid Activation The Carnitine Shuttle Import via carnitine commits fatty acid to oxidation. BCH 227 FALL 2010
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Lecture28 - BCH 227 FALL 2010 LECTURE 28 OXIDATION OF FAT 8...

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