Lecture29 - BCH 227 FALL 2010 LECTURE 29: OXIDATION OF FAT...

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1 Oxidation of Fat BIOCHEM 227 FALL 2010 Lecture 29 Wednesday, November 10, 2010 TODAY • Oxidation of Fat in Peroxisomes • Glyoxylate Cycle vs. Ketone Bodies • Intro to Nitrogen Metabolism BCH 227 FALL 2010 LECTURE 29: OXIDATION OF FAT CONT. 10 NOV 2010
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2 Oxidation of Fat in Peroxisomes Peroxisomes • Centers for oxidative metabolism – detoxification – fatty acid oxidation – biosynthesis BCH 227 FALL 2010 LECTURE 29: OXIDATION OF FAT CONT. 10 NOV 2010
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3 Peroxisomes •u s e O 2 to oxidize molecules directly – removal of H 2 from substrate (oxidation) –O 2 becomes H 2 O 2 (reduction) catalase uses H 2 O 2 in subsequent oxidations, and also converts it back to water H 2 O 2 + RH 2 →R ±+ ±2H 2 O 2H 2 O 2 →2H 2 O + O 2 FYI: humans process ~25% of EtOH this way! Peroxisome β Oxidation •P l an
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4 Peroxisome β Oxidation • First oxidation step (production of alkene) – FAD passes 2 e - to O 2 –Makes H 2 O 2 • Other steps are the same Peroxisome β Oxidation BCH 227 FALL 2010 LECTURE 29: OXIDATION OF FAT CONT.
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5 The Glyoxylate Cycle
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This note was uploaded on 12/19/2010 for the course BIOCHEM 227 taught by Professor Coggins during the Fall '10 term at Duke.

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Lecture29 - BCH 227 FALL 2010 LECTURE 29: OXIDATION OF FAT...

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