Lecture30 - BCH 227 FALL 2010 LECTURE 30: NITROGEN...

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1 Nitrogen Metabolism Amino Acid Oxidation BIOCHEM 227 FALL 2010 Lecture 30 Friday, November 12, 2010 TODAY • Intro to Nitrogen Metabolism BCH 227 FALL 2010 LECTURE 30: NITROGEN METABOLISM AND AMINO ACID OXIDATION 12 NOV 2010
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2 Introduction to Nitrogen Metabolism Nitrogen in Biology • An important component in many molecules – amino acids – nucleotides – cofactors, vitamins, etc. BCH 227 FALL 2010 LECTURE 30: NITROGEN METABOLISM AND AMINO ACID OXIDATION 12 NOV 2010
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3 The Nitrogen Cycle Nitrogen Fixation •NH 3 is made from N 2 by nitrogen-fixing bacteria – often found in root nodules of plants (legumes) • Difficult because of high E A • Carried out by nitrogenase BCH 227 FALL 2010 LECTURE 30: NITROGEN METABOLISM AND AMINO ACID OXIDATION 12 NOV 2010
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4 Nitrogen Metabolism in Humans • Source: amino acids in protein • Stored as amino acids – free, in the blood – in the muscles, as muscle protein –as other prote ins • When not needed, excreted – moved as Gln, Ala to liver – converted to urea Inside a Normal Cell • Transamination – Move N between Glu and other amino acids – Glu is the main storage for N • Excess N sent to liver via Gln, Ala BCH 227 FALL 2010
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This note was uploaded on 12/19/2010 for the course BIOCHEM 227 taught by Professor Coggins during the Fall '10 term at Duke.

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Lecture30 - BCH 227 FALL 2010 LECTURE 30: NITROGEN...

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