Lecture31 - BCH 227 FALL 2010 LECTURE 31: UREA CYCLE &...

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1 The Urea Cycle Amino Acid Oxidation BIOCHEM 227 FALL 2010 Lecture 31 Monday, November 15, 2010 TODAY • Revisit: Transamination Mechanism •Th e U r e a
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2 Transamination 1 Transamination 2 BCH 227 FALL 2010 LECTURE 31: 15 NOV 2010
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3 Transamination 3 Transamination 4 BCH 227 FALL 2010 LECTURE 31: 15 NOV 2010
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4 The Urea Cycle N Metabolism in the Liver BCH 227 FALL 2010 LECTURE 31: 15 NOV 2010
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5 Urea Cycle • Disposes of NH 4 + as urea • Each turn of the cycle… – disposes of 2 NH 3 groups –takes up 1 st NH 4 + as carbamoyl phosphate –gets 2 nd NH 3 from Asp – uses 3 ATP, but releases fumarate • fumarate → 1 NADH → 2.5 ATP Urea Cycle BCH 227 FALL 2010
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6 Urea Cycle Enzymes: 1. ornithine transcarbamoylase 2. arginosuccinate synthetase 3. arginosuccinase 4. arginase • Formation of carbamoyl phosphate requires 2 ATP BCH 227 FALL 2010 LECTURE 31: 15 NOV 2010
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This note was uploaded on 12/19/2010 for the course BIOCHEM 227 taught by Professor Coggins during the Fall '10 term at Duke.

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Lecture31 - BCH 227 FALL 2010 LECTURE 31: UREA CYCLE &...

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