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Lecture32 - BCH 227 FALL 2010 LECTURE 32 AMINO ACID...

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1 Amino Acid Oxidation Fatty Acid Synthesis BIOCHEM 227 FALL 2010 Lecture 32 Wednesday, November 17, 2010 TODAY • Continuation: Amino Acid Oxidation Fatty Acid Synthesis – chemistry – FAS complex – elongation – desaturation – PKS complexes BCH 227 FALL 2010 LECTURE 32: AMINO ACID OXIDATION; FATTY ACID SYNTHESIS 17 NOV 2010
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2 A Few More Examples Thr, Gly, Ser – to pyruvate Gly can also be cleaved to NH 4 + , CO 2 & methyl No transamination! Thr BCH 227 FALL 2010 LECTURE 32: AMINO ACID OXIDATION; FATTY ACID SYNTHESIS 17 NOV 2010
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3 Thr, Gly, Ser Tetrahydrofolate (THF) Dietary vitamin folate/folic acid Used to transfer “1 carbon” groups – methyl, methylene, formyl, etc. Gets methyls from Ser – Ser → Gly Also critical for nucleotide synthesis – dihydrofolate reductase: chemo target BCH 227 FALL 2010 LECTURE 32: AMINO ACID OXIDATION; FATTY ACID SYNTHESIS 17 NOV 2010
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4 Tetrahydrofolate (THF) Thr, Gly, Ser, Ala, (part of) Trp BCH 227 FALL 2010 LECTURE 32: AMINO ACID OXIDATION; FATTY ACID SYNTHESIS 17 NOV 2010
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5 Gly Cleavage Generates methyl for THF – a way to “charge” THF with methyls – another way is to move from Ser (making Gly) A Third Gly Pathway BCH 227 FALL 2010 LECTURE 32: AMINO ACID OXIDATION; FATTY ACID SYNTHESIS 17 NOV 2010
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6 A Few More Examples Arg, Pro, His – connects to ornithine of urea cycle Pro & Glu closely connected
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