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Lecture34 - BCH 227 FALL 2010 LECTURE 34 GLYCOGEN INSULIN...

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1 Glycogen Metabolism Insulin and Glucagon BIOCHEM 227 FALL 2010 Lecture 34 Monday, November 20, 2010 TODAY • Glycogen Insulin and Glucagon BCH 227 FALL 2010 LECTURE 34: GLYCOGEN; INSULIN & GLUCAGON 22 NOV 2010
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2 Glycogen Synthesis Chain extended by glycogen synthase Branches introduced by branching enzyme Glycogen Synthesis BCH 227 FALL 2010 LECTURE 34: GLYCOGEN; INSULIN & GLUCAGON 22 NOV 2010
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3 Glycogen Synthesis Glycogen Degradation Chains are disassembled by glycogen phosphorylase – removal from nonreducing end – phosphate is attached to departing sugar → produces glucose-1-phosphate (conserves energy from the glycosidic bond) – continues until 4 residues from a branch BCH 227 FALL 2010 LECTURE 34: GLYCOGEN; INSULIN & GLUCAGON 22 NOV 2010
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4 Glycogen Degradation Glycogen Degradation BCH 227 FALL 2010 LECTURE 34: GLYCOGEN; INSULIN & GLUCAGON 22 NOV 2010
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5 What Happens to the Glucose? Glucose-1-phosphate → glucose-6-phosphate phosphoglucomutase • Glycolysis • Liver: release to blood
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