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BIOMATFinalExam - Name Biomaterials and Biocompatibility...

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Name: ______________________ Biomaterials and Biocompatibility Final Exam – MME program Spring 2006 No collaborations between students or help for any other sources. Open book and notes permitted. Exams are due by 6:30 pm Monday June 5 th . This exam is worth 52 point total. Homework assignments total 48 points. Each question on this exam has different point values as noted. Sub-parts of each question are worth evenly divided fractions of the questions point value. Questions 3 & 4 have penalties for wrong answers as explained at the end of the exam. 1 . (8-points) Cross out those factors that do not directly contribute to the assessment of biocompatibility (for example, from the FDA standpoint) a. activation of the complement system b. adsorption of fibronectin c. extractable polymerization initiators d. activation of blood platelets e. presence of jagged edges f. presence of hydroxyl groups g. toxicity to fibroblast cells h. presence of multinuclear giant cells i. surface wettability j integrin binding sites k. presence of endotoxin l. presence of carboxy groups m. surface protein denaturation n. porosity o. surgeon skill p. α -helix content q. B-cell activation r. activation of the intrinsic clotting system s. generation of C3q t. tissue necrosis u. the race to the surface v. nickel ion release w. polymeric degradation products that activate monocytes x. biomineralization y. ethylene oxide sterilization residues z. cell release of tissue necrosis factor α (TNF- α ) 2 . (10-points) Osteoarthritis is a huge healthcare problem with over 20 million diagnoses each year at a treatment cost of $12+ billion in the U.S. alone. Hence, tissue engineering (regeneration) of articular cartilage is being heavily pursued by numerous research groups. If you were to join one of these teams, briefly (in 1 page or less) discuss the biomechanical factors you would consider in establishing the “functional” requirements for the tissue-engineered cartilage. In your discussion, consider the following questions: a. What is the mechanical environment for articular cartilage? (Consider the structure- Final Exam MME 2006 Biomaterials and Biocompatibility page 1 of 6
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Name: ______________________ function-property relationship) b. What are the biomechanical tests that you could/should perform to provide data for design and development of the regenerated cartilage? (Discuss and describe) c. What would be your biomechanical criteria for success? (How would you know when it was good enough?) d. What other tests would you suggest to establish efficacy of the engineered cartilage? 3 . (8-points) ( Some of these multiple choice problems have none, one, more than one, or all correct answers. Circle only the ones you think are the correct answers; don’t guess, as points will be deducted for wrong answers. An example is shown at the bottom relevant to question 3 and question 4.* ) a. Polyethylene is a semi-crystalline polymer because a) the chains have a regular, streamlined shape
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BIOMATFinalExam - Name Biomaterials and Biocompatibility...

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