PPT_Chapter_28.ppt - Drugs That Affect the Stomach and Pancreas Drugs That Affect the Gastrointestinal System Chapter 28 Copyright \u00a9 2013 Wolters

PPT_Chapter_28.ppt - Drugs That Affect the Stomach and...

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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Drugs That Affect the Stomach and Pancreas Drugs That Affect the Stomach and Pancreas Drugs That Affect the Gastrointestinal System Chapter 28
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Actions of Antacids Actions of Antacids Neutralize gastric hydrochloric acid Examples include: Aluminum hydroxide Calcium carbonate Magaldrate Magnesia or magnesium hydroxide Products may contain a single ingredient of two or more antacids
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Uses of Antacids Uses of Antacids Treatment of hyperacidity problems Heartburn, gastroesophageal reflux, sour stomach, acid indigestion, peptic ulcer Calcium carbonate also used for menopausal osteoporosis Magnesium salts also used for magnesium deficiencies or magnesium depletion from malnutrition, restricted diet, or alcoholism
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Adverse Reactions of Antacids Adverse Reactions of Antacids Magnesium- and sodium-containing Laxative effect Diarrhea Aluminum- and calcium-containing Constipation Combination products should result in an overall adverse reaction of little change on bowel movements if combine magnesium or sodium with aluminum or calcium
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Adverse Reactions of Antacids Adverse Reactions of Antacids Aluminum-containing antacids Constipation, intestinal impaction, anorexia, weakness, tremors, bone pain Magnesium-containing antacids Severe diarrhea, dehydration, hypermagnesemia
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Adverse Reactions of Antacids Adverse Reactions of Antacids Calcium-containing antacids Rebound hyperacidity, metabolic alkalosis, hypercalcemia, vomiting, confusion, headache, renal calculi, neurologic impairment Sodium bicarbonate Systemic alkalosis, rebound hypersecretion
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Contraindications, Precautions, and Interactions of Antacids Contraindications, Precautions, and Interactions of Antacids Contraindications: Severe abdominal pain of unknown cause Lactation Sodium-containing: cardiovascular problems, sodium-restricted patients Calcium-containing: renal calculi, hypercalcemia
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Contraindications, Precautions, and Interactions of Antacids Contraindications, Precautions, and Interactions of Antacids Precautions: Aluminum-containing: gastric outlet obstruction Magnesium- and aluminum-containing: decreased kidney function Calcium-containing: respiratory insufficiency, renal impairment, cardiac disease
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Contraindications, Precautions, and Interactions of Antacids Contraindications, Precautions, and Interactions of Antacids Interactions: Antacids interfere with other drugs in 3 ways:

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