CH 12 - CH.12.DNAStructureandFunction Objectives:

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CH. 12. DNA Structure and Function    Objectives :     1.     Understand how experiments using bacteria and viruses demonstrated that instructions          for producing heritable traits are encoded in DNA. 2.     Describe the building blocks of DNA and recognize proper base pairing. 3.     Describe the structure of a DNA molecule. 4.     Understand how DNA is replicated and repaired. 5.     Understand various ways that mammals can be cloned and the implications of such cloning.     Key Terms : DNA bacteriophages nucleotides deoxyribose adenine guanine thymine cytosine pyrimidines purines x-ray diffraction images double helix DNA replication semiconservative DNA polymerases DNA ligases DNA repair artificial twinning     Lecture Outline :          Impacts, Issues: Here Kitty, Kitty, Kitty        A.    Dolly was the first cloned mammal. 1.     This lamb was identical to the one from which the donor cell had been taken; 
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        she had no father’s contribution of genes. 2.     Dolly aged prematurely; her chromosomal telomeres were as short as the          six-year-old animal from which she had been cloned. B.    Cloning mammals is difficult. 1.     Not many nuclear transfers are successful; most individuals die before          birth or shortly thereafter. 2.     Those that do survive have many problems with individual organs. C.    The potential benefits of cloning are enormous, despite the ethical controversy. 1.     Replacement cells and organs may help those with incurable degenerative diseases. 2.     Extinct animals might be saved from extinction. 3.     Livestock production can be enhanced.         12.1.    The Hunt for Fame, Fortune, and DNA            A.   Early and Puzzling Clues                   1.   Johann Miescher is credited with the discovery of DNA in the late 1800s.                   2.   In 1928, Fred Griffith was working with S (pathogenic) and R (nonpathogenic) strains                         of a pneumonia-causing bacterium.                   3.   He performed four experiments summarized here.
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CH 12 - CH.12.DNAStructureandFunction Objectives:

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