06_-_dynamics_of_chemical_systems - Quantitative Physiology...

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Unformatted text preview: Quantitative Physiology I / Molecular and Cellular Systems, BMEN E4001x Notes 06 Numerical simulations Keener & Sneyd, section 1.3 Glycolysis and Glycolytic oscillations web-available Runge-Kutta and MATLAB resource Selkov model Glucose Fructose 6-P Fructose 1,6-P Pyruvate PFK1 Under certain conditions, this system exhibits oscillations. K&S has a full description of the history and interactions. Earlier, we discussed that PFK1 is inhibited by ATP, and also acts on ATP. In this model, assume that ADP provides a positive regulation on PFK1; need to generate more ATP. Specifically, assume: ATP is a substrate and inhibitor to PFK1 (source of phos. for creating F-1,6-P) Inhibition is removed by AMP Steady state doesnt capture full behavior Oscillations have been observed in yeast models Selkov model as a simplified explanation Goal: find reaction behavior as a function of input ATP binding of a certain number of ADPs, , (correlated to AMP) activates PFK1...
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This note was uploaded on 12/21/2010 for the course BMEN 4001 taught by Professor Kam during the Fall '10 term at Columbia.

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06_-_dynamics_of_chemical_systems - Quantitative Physiology...

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