Lect8 Epidemiology&Disease Mech

Lect8 Epidemiology&Disease Mech - Principles of...

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1 Principles of Diseases and Epidemiology Normal Microbiota Etiology of infectious diseases Classification of infectious diseases Patterns of disease Spread of infection Nosocomial infections Epidemiology of infectious diseases
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2 Definitions Pathology : The study of disease Etiology : The study of the cause of a disease Pathogenesis : The development of disease Infection : Colonization of the body by pathogens (not always causes disease) Disease : An abnormal state in which the body is not functioning normally
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3 Termites can’t digest wood?!
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4 Normal Microbiota and the Host Transient microbiota may be present for days, weeks, or months. Normal microbiota permanently colonize the host. Symbiosis is the relationship between normal microbiota and the host. Figure 14.1c
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5 Your body is an ecosystem! Symbiotic relationships Mutualism – both partners benefit ex: some bacteria in gut synthesize vitamin K and some B vitamins are absorbed by host bacteria are warm and have access to nutrients Commensalism – benefits one partner, other is unharmed ex: bacteria on skin not harmful but not advantageous to humans bacteria have access to nutrients Parasitism parasite benefits at the expense of host ex: all pathogens are parasites
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6 Normal Microbiota and the Host Microbial antagonism (or competitive exclusion) is a competition between microbes. Normal microbiota protect the host by: Occupying niches that pathogens might occupy Producing acids Producing bacteriocins ( E. coli v. Salmonella ) Probiotics are live microbes applied to or ingested into the body, intended to exert a beneficial effect.
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7 Normal Microbiota and the Host Locations of normal microbiota on and in the human body. Table 14.1c
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8 Normal human microbiota
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9 Normal → Opportunist Pathogen – microbe causing disease in healthy people Opportunistic pathogen – microbe may cause disease if opportunity arises Immune suppression Changes in normal micobiota Introduction of normal microbiota into unusual site in body
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10 Principles of Diseases and Epidemiology Normal Microbiota Etiology of infectious diseases Classification of infectious diseases Patterns of disease Spread of infection Nosocomial infections Epidemiology of infectious diseases
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11 How do we find causes for infectious disease? Koch's postulates are used to prove the cause of an infectious disease. Figure 14.3 (1 of 2)
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12 Koch’s Postulates 1. The suspected causative agent must be found in every case of the disease and be absent from healthy hosts. 2. The agent must be isolated and grown outside the host. 3.
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This note was uploaded on 12/29/2010 for the course BIOL 210 taught by Professor Gutiérrez during the Spring '10 term at Coastline Community College.

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Lect8 Epidemiology&Disease Mech - Principles of...

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