Lect11 West Nile Virus - West Nile Virus Presented by Alice...

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West Nile Virus Presented by Alice Nguyen, Mimi Yoo
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What is West Nile virus? WNV is a type of Arbovirus Arbovirus= virus from various families which are transmitted via arthropods West Nile Virus Family – Flaviviridae Genus – Flavivirus Diseases – West Nile Fever, West Nile Encephalitis, West Nile Meningitis
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Causal Agent: Flavivirus Morphology: Spherical, icosahedron made up of triangular facets 50 nm in diameter Genome: Single stranded RNA Consist of mainly a membrane envelope and a dense core Enters host cell in similar way to endocytosis Replicate in cells of host Use cell proteins during their replication cycle for attachment, entry, translation, transcription and replication, and assembly
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Reservoir, Vector, hosts WNV must have a vector to transmit to a host •Birds= natural hosts •Mosquitoes= vectors •Human, horses, & other domestic animals= incidental hosts/dead end hosts •Virus does not multiply in the blood to levels high enough to be able to transmit to the next host.
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Genus Culex WNV is transmitted primarily by the Culex mosquitoes
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Method of Transmission/Incubation Virus circulates in mosquito’s blood for a few days and ending in their salivary glands Infects the next animal or human when the mosquito bite to take in blood Incubation period in human is 2 to 15 days Only a small case of transmission through Organ donation Blood transfusions Breast milk – no illness resulted Only one case of mother to child during pregnancy
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Statistics Less than 1% of mosquitoes carry the virus 80% of people infected remain asymptomatic 20% of people infected will develop West Nile Fever Fewer than 1 in 150 people who get the virus will develop severe form of West Nile Encephalitis – risk of death in this group is 11% Overall risk of dying from West Nile Virus infection is less than 1 per 1000
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This note was uploaded on 12/29/2010 for the course BIOL 210 taught by Professor Gutiérrez during the Spring '10 term at Coastline Community College.

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Lect11 West Nile Virus - West Nile Virus Presented by Alice...

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