320Fall10Lecture15 - 1 BIO 320 Cell Biology, Fall 2010 Dr....

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BIO 320 Cell Biology, Fall 2010 Dr. Thomas Bushart Week 15 1
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Pathogens Infectious agents Viruses, bacteria, fungi, protozoa, etc Fulfill their “biological imperative” to live and reproduce at expense of host Manifestation of illness can be due to either pathogen or host response 2
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Being pathogenic Virulence genes encode virulence factors Host-interacting proteins Toxic to host, benefits to pathogen Delivery system Difference between disease causing and benign pathogens can be very small 3
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Type III secretion system Syringe-like injection system for the delivery of proteins and chemicals necessary for the pathogen Similar structurally to the base of flagella 4
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Infection Plants and animals both have passive protection Skin and waxy cuticles of leaves Chemically hostile environments (stomach acid) Pathogens need to circumvent barriers and establish themselves Typically also need an exit method to infect new hosts 5
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Plants and bacteria Stomata are vulnerable points of entry on a leaf Need to be open for gas exchange during daylight Stomata close when exposed to bacteria Plant-infecting bacteria secrete a hormonal mimic to prevent stomate closure 6
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Adhesion Pathogens need to avoid clearance Mucus linings and movements (cilia or fluid) will remove pathogens Adhesion molecules Kidney/bladder, respiratory, and stomach bacteria have cell-surface binding proteins Glycolipids are a common target Bordetella pertussis binds to ciliated cells and kills them Decreases general clearance ability 7
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Enteropathogenic E. coli Insert their own adhesion proteins into the host’s cells 8
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This note was uploaded on 12/30/2010 for the course BIO 320 taught by Professor Staff during the Spring '08 term at University of Texas at Austin.

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320Fall10Lecture15 - 1 BIO 320 Cell Biology, Fall 2010 Dr....

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