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Unformatted text preview: • Wnts act by binding to both a Frizzled protein and a co-receptor protein • Beta-catenin in junctions helps link the cadherins to the actin cytoskeleton Planar polarity pathway Wnt/Ca2+ pathway o All 3 pathways begin with binding of Wnts to Frizzled family cell-surface receptors o Frizzled receptors are 7-pass transmembrane proteins that resemble GPCRs in structure o When activated by Wnt binding, Frizzled proteins recruit the scaffold protein Dishevelled o Degradation of cytoplasmic beta-catenin depends on degradation complex o LOOK AT PICTURE ON 949 • Hedgehog proteins bind to patched, relieving its inhibition of smoothened o • Many stressful and inflammatory stimuli act through an NFB dependent signaling pathway...
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- Spring '08
- NFB, transmembrane protein Notch, receptor protein notch