1150- 1164 Tight Junctions and the organization of Epithelia

1150- 1164 Tight Junctions and the organization of...

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Tight Junctions and the organization of Epithelia Basal side they are anchored to other tissue, on the apical side they are free of such attachement. All epithelia are polarized. Epithelia serve as selective permeability barriers. Barrier function requires occluding junctions to seal, so crap cant leak freely across the cell sheet. Junctions are a key part in organizing and maintaining the polarity of the cells in the sheet. Tight junctions form a seal between cells and a fence between membrane domains o Occluding junctions found in vertebrate epithelia are called tight junctions o Tight junctions confine transport proteins to their appropriate membrane domains by acting as diffusion barriers o Junctions also block backflow of glucose from basal side into guy lumen o Apical set of active transport proteins must be delivered to the cell apex and must not be allowed to drift to basolateral surface o Basolateral set of channel proteins must be delivered to basolateral surface and must
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