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1150-1164 Cell junctions

1150-1164 Cell junctions - Cell junctions cell adhesion and...

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Cell junctions, cell adhesion, and the extracellular matrix Cadherins and cell-cell adhesion Connective tissue like bone or tendon, matrix is rich with collagen, and it’s the matrix (rather than the cells) that bears the stress. Epithelial tissues are bound onto sheets called epithelia. Anchoring junctions includes both cell-cell adhesions. Occluding junctions seal the gaps between cells in epithelia. Channel-forming junctions create passways Signal relaying junctions allow signals to be relayed from cell to cell across their plasma membrane Adherens junctions are anchorage sites for actin filaments Desmosome junctions are anchorage sites for intermediate filaments Actin-linked cell matridx adhesions anchor actin filaments to the matrix Hemidesmosomes anchor intermediate filaments to it Transmembrane adhesion proteins are in each of the 4 junctions These are cytoskeleton linked transmembrane molecules which fall into 2 families Proteins of CADHERIN superfamily mediate attachment o cell to cell Proteins of INTEGRIN superfamily mediate attachment of cells to matrix Some cadherins link to actin and form adherens junctions Some cadherins link to intermediate filaments and form desmosome junctions Some integrins link to actin and make actin linked cell matrix adhesions
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