1164-1180 THE BASAL LAMINA

1164-1180 THE BASAL LAMINA - THE BASAL LAMINA Basal laminae...

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THE BASAL LAMINA Basal laminae underlie all epithelia and surround some nonepithelial cell types o Basal lamina separates these cells and epithelia from the underlying or surrounding connective tissue and forms the mechanical connection between them o Basal laminae can determine cell polarity, influence cell metabolism, organize the proteins in adjacent plasma membranes, promote cell survival, proliferation, or differentiation o In skin, the epithelial outer layer (epidermis) depends on strength of the basal lamina to keep it attached to the underlying connective tissue (dermis) o Mutants have their epidermis detached from the dermis Laminin is a primary component of the basal lamina o Basal lamina is between the epithelial cells and connective tissue o Basal lamina is made of 2 extracellular macromolecules: Fibrous proteins (like glycoproteins) Polysaccharide chains (glycosaminoglycans) o GAGs are linked to core proteins to form proteoglycans o Basal lamina contains laminin, type 4 collagen, nidogen, perleacan
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1164-1180 THE BASAL LAMINA - THE BASAL LAMINA Basal laminae...

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