BIO320BushartFall10_10am - BIO 320 Cell Biology, Fall 2010...

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BIO 320 Cell Biology, Fall 2010 48880-48895 MWF 10:00am – 11:00am, BUR 216 Instructor Teaching Assistant Name: Dr. Thomas Bushart Devin Fraley Office: Biological Laboratory room 6 BIO 15 Phone: 471-1074 471-1074 E-mail: Office hours: TBA and by appointment TBA and by appointment Introduction Per the course catalog, this Cell Biology class covers the “Principles of eukaryotic cell structure and function; macromolecules, energetics, membranes, organelles, cytoskeleton, gene expression, signaling, division, differentiation, motility, and experimental methodologies.” For all practical purposes, these topics are simply the details of the general concepts covered in Introductory Biology I and so should not be intimidating. While the introductory classes you have already passed laid the foundations of biology with broad concepts and themes (hopefully, anyway) this class approaches from the other direction. Working from an established framework, we can examine specific models and details so that you can better understand how the larger picture of a living cell is actually composed of many minute and interrelated processes. We will start the class with a brief overview and review of the basics of molecules important to a cell. The compartmentalization of eukaryotic cells will be examined by looking at the properties of membranes (which are much more than just lipid bilayers) and how proteins and other substances are transported to and through them. The movements of membranes themselves are important to the viability of a cell and so we will look at membrane trafficking through the various organelle systems. All of this internal movement is dependent on the internal scaffolding of the cytoskeleton, which is also used in whole-cell motility, the ability of cells to interact with their neighbors, and cell division. With that in mind, we will take a look at cell junctions and communications in the framework of cell-to-cell interactions. Finally, we will look at how pathogens can co-opt a cell’s machinery in the process of infection. Class Requirements and Policies 978-0-8153-4105-5 cell molecular bioloy of the cell 5th 978-0136078685 mis – experiencing mis Essential Biochemistry , 2nd Edition; Pratt and Cornely CFIN , 1 st edition, written by Scott Besley and Eugene Brigham, Text : Molecular Biology of the Cell (Fifth Edition, 2008), B. Alberts, A. Johnson, et al., Garland Science. There are copies of the text on reserve at the Life Sciences Library. You may use the fourth edition of the textbook if you so choose, but MBotC is an excellent resource so I recommend the most current edition and there should be used copies available. There
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may be supplemental articles provided during the course. These will be delivered via hardcopy, online links, and/or electronically on Blackboard.
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BIO320BushartFall10_10am - BIO 320 Cell Biology, Fall 2010...

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