homework7 - Cell Biology (BIO 320), Fall 2010, Dr. Bushart...

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Cell Biology (BIO 320), Fall 2010, Dr. Bushart Homework 7, for quizzes the week of 10/25 1. Based on the textbook’s description of transferrin and its receptor (p. 794), how would you modify the figure for cholesterol uptake (Figure 13-53) to depict the endo/exocytosis of these components in the cell? 2. The depictions of endosomes in the book include an arm like projection from which exiting vesicles from. One effect of this is to shrink the ratio of liquid to membrane in order to limit random uptake of soluble components. In addition to that benefit, why would a small tube of membrane (instead of a sphere of the same volume) increase the efficiency of vesicle formation? 3. There are a number of lysosomal diseases. One particular form, called I-cell disease, stems from the inability of the cells to correctly tag their enzymes with M6P. a. Where will these enzymes lacking M6P tags end up? Why? The default pathway for proteins is delivery to the plasma membrane. Since these enzymes cannot be recognized by the M6P receptors they will end up outside the cell. b.
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homework7 - Cell Biology (BIO 320), Fall 2010, Dr. Bushart...

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