_Homework_homework2notes

_Homework_homework2notes - How to approach Homework 2,...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
How to approach Homework 2, problem 1 Let the possible doses be denoted d 1 , . . . , d I . At dose d i , let the probability of a dose- limiting toxicity be p i and write q i = 1 - p i . Let’s create some additional notation. Define U i to be the probability that you escalate from d i to d i +1 . Note that U I = 0. And let B i be the probability that you go back down from d i , given that you got to d i somehow (that is, the conditional probability that you declare d i not safe given that you got there somehow). Note that if you find that the lowest dose is not safe, you’d declare there to be no safe dose. Note that the first time you treat 3 patients at dose d i , there are three possibilities: If you get 2 or 3 toxicities, you go back down right away, and you never do this dose again. If this was the lowest dose, then there is no safe dose. If you get 0 toxicities, you go up to dose d i +1 unless you are already at dose d I , in which case you do three more here. If you get 1 toxicity, you give 3 more patients the same dose.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/30/2010 for the course BST 252 taught by Professor Tsodikov during the Winter '06 term at UC Davis.

Page1 / 2

_Homework_homework2notes - How to approach Homework 2,...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online