{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

_Homework_samplefinalreport

_Homework_samplefinalreport - Sample Text for Final Report...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Sample Text for Final Report for BST/STA 225, Spring 2006 Loosely modeled on Armstrong et al. (2005). Intraperitoneal cisplatin and paclitaxel in ovarian cancer. New Engl. J. Med. 354; 34-43. Statistical methods The UC Davis Division of Biostatistics randomly assigned patients to one of the two treatment groups. A sample size of 500 eligible patients was set, with sufficient follow-up to observe at least 350 deaths before final testing of the primary hypothesis, which was based on the following research question: Does the addition of BST-KIT to standard cisplatin plus irinotecan therapy increase survival in chemotherapy-naïve SCLC patients with late-stage disease, compared to cisplatin and irinotecan alone? This sample size provided 80% power to detect a hazard ratio of 1.33, using a log-rank test, an alpha level of 0.05, and a two-sided test ( www.swogstat.org/stat/public /survival_twoarm.htm). No interim analyses were planned, due to the comparatively rapid accrual expected for this study. The primary study endpoint was survival, measured from date of randomization to date of death or, for patients still alive, to date of last contact. The planned analysis included all eligible patients (intent-to-treat). Estimates of the cumulative proportion surviving used
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern