_Homework_samplefinalreport

_Homework_samplefinalreport - Sample Text for Final Report...

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Sample Text for Final Report for BST/STA 225, Spring 2006 Loosely modeled on Armstrong et al. (2005). Intraperitoneal cisplatin and paclitaxel in ovarian cancer. New Engl. J. Med. 354; 34-43. Statistical methods The UC Davis Division of Biostatistics randomly assigned patients to one of the two treatment groups. A sample size of 500 eligible patients was set, with sufficient follow-up to observe at least 350 deaths before final testing of the primary hypothesis, which was based on the following research question: Does the addition of BST-KIT to standard cisplatin plus irinotecan therapy increase survival in chemotherapy-naïve SCLC patients with late-stage disease, compared to cisplatin and irinotecan alone? This sample size provided 80% power to detect a hazard ratio of 1.33, using a log-rank test, an alpha level of 0.05, and a two-sided test ( www.swogstat.org/stat/public /survival_twoarm.htm). No interim analyses were planned, due to the comparatively rapid accrual expected for this study. The primary study endpoint was survival, measured from date of randomization to date of death or, for patients still alive, to date of last contact. The planned analysis included all
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This note was uploaded on 12/30/2010 for the course BST 252 taught by Professor Tsodikov during the Winter '06 term at UC Davis.

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_Homework_samplefinalreport - Sample Text for Final Report...

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