_Homework_samplefinalreport - Sample Text for Final Report...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Sample Text for Final Report for BST/STA 225, Spring 2006 Loosely modeled on Armstrong et al. (2005). Intraperitoneal cisplatin and paclitaxel in ovarian cancer. New Engl. J. Med. 354; 34-43. Statistical methods The UC Davis Division of Biostatistics randomly assigned patients to one of the two treatment groups. A sample size of 500 eligible patients was set, with sufficient follow-up to observe at least 350 deaths before final testing of the primary hypothesis, which was based on the following research question: Does the addition of BST-KIT to standard cisplatin plus irinotecan therapy increase survival in chemotherapy-naïve SCLC patients with late-stage disease, compared to cisplatin and irinotecan alone? This sample size provided 80% power to detect a hazard ratio of 1.33, using a log-rank test, an alpha level of 0.05, and a two-sided test ( www.swogstat.org/stat/public /survival_twoarm.htm). No interim analyses were planned, due to the comparatively rapid accrual expected for this study. The primary study endpoint was survival, measured from date of randomization to date of death or, for patients still alive, to date of last contact. The planned analysis included all
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/30/2010 for the course BST 252 taught by Professor Tsodikov during the Winter '06 term at UC Davis.

Page1 / 2

_Homework_samplefinalreport - Sample Text for Final Report...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online