_Dr. Miller's lecture_chemokine_lecture_1

_Dr. Miller's lecture_chemokine_lecture_1 - Chemokine...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
Chemokine Biology I. Organization and description of chemokine/chemokine receptor superfamilies I. Mechanisms of chemokine function
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Number of chemokine publications 1991 approx. 1600 publications 2003 approx. 21,000 publications
Background image of page 2
Cytokines 1.Produced during effector phases of natural and specific immunity; serve to mediate and regulate immune & inflammatory responses 2.Secretion is a transient event 3.Produced by multiple cell types 4.Act upon multiple cell types 5.Multiple effects on the same target cell 6.Actions are redundant 7.Often influence the synthesis and action of other cytokines 8.Bind to specific receptors on surface of target cell
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Chemokines (chemoattractant cytokines) are a family of small peptides (8-12 kDa) whose main biologic function is to deliver certain leukocyte populations to localized sites of function
Background image of page 4
Chemotaxis directional migration in response to gradients of soluble factors Haptotaxis directional migration in response to gradients of substrate bound factors Chemokinesis random migration in response to soluble factors
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
In Vitro Chemotaxis assay membrane insert medium chemokine
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 30

_Dr. Miller's lecture_chemokine_lecture_1 - Chemokine...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online