_Dr. Powell's lecture_angiogenesis_pmi_285_feb_2004_lecture_3

_Dr. Powell's lecture_angiogenesis_pmi_285_feb_2004_lecture_3

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Angiogenesis PMI 285 February 19, 2004 1. Process of New Capillary Growth 1. Basement Membrane is degraded. 2. Endothelial cell is activated from quiescent state 3. Migration of endothelial cell 4. Proliferation of endothelial cells behind the leading tip of the budding vessel 5. Tube formation – requires a three dimensional matrix 6. Loop formation and blood flow 7. New basement membrane formed 8. Maturation of endothelial cells and phenotypic differentiation 2. Regulation of vascular morphogenesis: Embryonic liver : angioblasts produce hematopoiesis (growth factors not known) and vascular structures – under the influence of VEGF VEGF Receptors, different receptors for proliferation and for tube formation Experiment: transgenic knockout mice are embryonic lethal due to lack of blood vessels in the liver. VEGF also required for formation of lymphatic system. Adult : the situation is less clear: there are dozens of factors that promote angiogenesis. 1.
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This note was uploaded on 12/30/2010 for the course PMI 285 taught by Professor Wu during the Winter '04 term at UC Davis.

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