AngiogenesisPMI 285 February 19, 20041. Process of New Capillary Growth1.Basement Membrane is degraded.2.Endothelial cell is activated from quiescent state3.Migration of endothelial cell4.Proliferation of endothelial cells behind the leading tip of the budding vessel5.Tube formation – requires a three dimensional matrix6.Loop formation and blood flow7.New basement membrane formed 8.Maturation of endothelial cells and phenotypic differentiation2. Regulation of vascular morphogenesis:Embryonic liver: angioblasts produce hematopoiesis (growth factors not known)and vascular structures – under the influence of VEGFVEGF Receptors, different receptors for proliferation and for tube formation Experiment:transgenic knockout mice are embryonic lethal due to lack of blood vessels in the liver. VEGF also required for formation of lymphatic system.Adult: the situation is less clear: there are dozens of factors that promote angiogenesis.
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