_Dr. Powell's lecture_pmi_2004_lecture_1

_Dr. Powell's lecture_pmi_2004_lecture_1 - PMI 285 Cellular...

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PMI 285 Cellular Basis of Disease Vasculature Jerry S. Powell, M.D. [email protected] 916 734 8616 Vascular Permeability and edema Vascular Response to injury Angiogenesis Aspects of Coagulation and Thrombosis
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Functions Material Exchange – nutrients, waste Control of vascular tone Angiogenesis Control of Coagulation and Thrombosis Control of response to injury, inflammation
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Microcirculation - mesentery
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Structural Types of Endothelium Continuous muscle, skin, GI Fenestrated kidney, choroid Discontinuous hepatic, splenic Tight Junction CNS, retina e.g. blood brain barrier examples Type
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Continuous glycocalyx Basement membrane Solutes, lipid insoluble molecules, Plasma proteins Receptor mediated Transport pathways pinocytosis
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Fenestrated 5 – 50 % of surface is 0.05 um thick ( fenestrae ) generally less thick endothelium glycocalyx Basement membrane Solutes, lipid insoluble molecules, Plasma proteins Receptor mediated Transport pathways pinocytosis
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Discontinuous
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