_heat-shock response article_ch310imageindex

_heat-shock response article_ch310imageindex - Cont ent s...

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Contents Previous Next Chapter 310 The Heat-Shock Response: Sensing the Stress of Misfolded Proteins Richard I. Morimoto and Ellen A. A. Nollen Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois Add to Presentation Figure 1 Conditions that activate the heat-shock response. Heat-shock gene expression is induced byenvironmental and physiological stress, nonstressful conditions including cell growth and development, pathophysiological states, and protein aggregation diseases, that is, conditions that are associated with the appearance of misfolded proteins. Activation of the heat-shock transcription factor leads to the expression of heat-shockproteins, which function to prevent and repair protein damage through interaction with the misfolded proteins. View PDF Add to Presentation Figure 2 Regulation of the heat-shock response. Activation of HSF1 is linked to the appearance of
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This note was uploaded on 12/30/2010 for the course PMI 285 taught by Professor Wu during the Winter '04 term at UC Davis.

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_heat-shock response article_ch310imageindex - Cont ent s...

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