_slides_pmi285-wu-1-jan_04

_slides_pmi285-wu-1-jan_04 - Etiology of Cell Injury and...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
Etiology of Cell Injury and Diseases • Impaired energy production • Impaired cell membrane function • Metabolic derangement • Genetic alteration
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Impaired Energy Production (1) ADP + Pi Energy production Carbohydrate Lipid Catabolism Protein Energy utilization Biosynthesis of macromolecules Muscle contraction Active ion transport Thermo genesis ( G 0 = -7.4 kcal/mole) ATP
Background image of page 2
Impaired Energy Production (II) glycogen glucose-6-P NADPH 2 acetyl-CoA TCA NADH ATP O 2 6-phosphogluconate Pentose phosphate shunt 2 pyruvate DNA damage lactate CO 2 Poly-ADP ribosylation
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Impaired Energy Production (III) Hypoxic Injury e.g. myocardial infarction deprive oxygen Stop oxidate phosphorylation in mitochondria ATP and creatine phosphate deprivation Activation of anaerobic glycolysis Accumulation of lactic acid Reducing intracellular pH Cell membrane swelling Membrane permeable Release lysosomal enzymes Digesting cellular components
Background image of page 4
Impaired Cell Membrane Function Oxidant stress, Free radical injury Radiation Bacterial infection Enzymatic digestion. Lipid peroxidation Changes in permeability Changes in Calcium level
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Metabolic Derangement Abnormal adsorption Abnormal metabolism Accumulation Conversion Alcohol Heavy metals Prion Infectious agents
Background image of page 6
Genetic Alteration Mutation Mitosis arrest Change in gene expression Transformation Inherited genetic defect Acquired genetic abnormality
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 26

_slides_pmi285-wu-1-jan_04 - Etiology of Cell Injury and...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online