BIO 314 Practice Test 3

BIO 314 Practice - 1 p53 mice are a likely to develop tumors because a mutation in one allele is enough to induce cancer b unlikely to develop

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1) p53 +/- mice are a) likely to develop tumors because a mutation in one allele is enough to induce cancer b) unlikely to develop tumors because a mutation in one allele is not enough to induce cancer c) unlikely to develop tumors because apoptosis will not be induced d) likely to develop tumors because apoptosis will destroy healthy cells 2) p53 does not regulate a) cell cycle arrest b) DNA repair c) apoptosis d) angiogenesis e) all of the above are regulated by p53 3) MDM2 does not a) mark p53 for degradation by proteosomes b) bind to phosphorylated p53 and promote degradation c) get sequestered in the nucleolus when Arf binds to it d) MDM2 does all of the above 4) Concerning apoptosis… A) Apoptosis is programmed cell death that can be seen during various stages of development. B) Apoptosis is a discrete, genetically uncontrolled, evolutionarily variable, predictable, reproducible program of cell dissolution. C) Apoptosis eliminates damaged and deranged cells, therefore it is tumor suppressive.
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D) Apoptosis is accidental or injury induced cell death. E) Choices A and C only. 5) Of the following, which is an incorrect statement? A) Tumor cells have elevated levels of mutant p53 protein. Mutant p53 is unable to transactivate mdm2, so p53 is not degraded. B) Survival signals promote mdm2 expression while stress signals promote p53 stabilization. C) Stress kinases phosphorylate p53 and mdm 2 which disrupt the p53:mdm2 interaction and therefore stabilize the p53 protein. D) The phosphorylation of p53 sees p53 levels deplete rapidly which promotes growth arrest and apoptosis. E) All of the above statements are incorrect. 6) Concerning apoptosis… A) Cells dissolve when apoptosis activate a family of enzymes (nucleases, proteases, etc) that systematically “digest” the cell. B) Apoptosis is responsible for death of anoxic tissue, tissue that lost some content of oxygen, following an event such as a stroke or heart attack. The resulting tissue is considered ischemic. C) Apoptosis may also play a role in neuro-degenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). D) The remains of the apoptotic cell are phagocytose’d by macrophages. E) All of the above concerns apoptosis. 7) Of the following, which is an incorrect statement? A) Pro-apoptotic is equivalent to anti-survival.
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B) Pro-survival is equivalent to anti-apoptotic. C) Pro-survival is considered “bad” because it promotes cancerous growth. D) Pro-survival is considered “good” because it promotes cellular growth and regulation.
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This note was uploaded on 01/04/2011 for the course BIO 314 taught by Professor Erster,s during the Spring '08 term at SUNY Stony Brook.

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BIO 314 Practice - 1 p53 mice are a likely to develop tumors because a mutation in one allele is enough to induce cancer b unlikely to develop

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