BIO 314 Spring Exam 1 Practice Questions

BIO 314 Spring Exam - includes A PDGF/PDGF-R B EGF HER2 C Sis/PDGF-R D A& B E All of the Above Q4 Herceptin A Is a monoclonal antibody targeting

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Chapter 5 Slides 26-50 Study Questions Q1: Structural alterations that result in ligand-independent receptor dimerization and/or trans- phosphorylation may be due to: A. Gene fusions. B. Point mutations. C. Small deletions. E. All of the above. Q2: Over-expression of growth factor receptors may lead to: A. Spontaneous ligand-independent receptor dimerization. B. Dimerization and trans-phosphorylation in response to trace amounts of growth factor. C. Increased auto-inhibition of growth factor receptors. E. All of the above. Q3: An example of a growth factor/tyrosine kinase receptor complex involved in tumor pathogenesis
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Unformatted text preview: includes: A. PDGF/PDGF-R. B. EGF/ HER2. C. Sis/PDGF-R. D. A & B. E. All of the Above. Q4: Herceptin: A. Is a monoclonal antibody targeting the extracellular domain of HER2. B. Led to a magnified response of HER2 to EGF, causing excessive proliferation. C. Prevents receptor degradation and the recruitment of immune cells. D. B & C. E. All of the Above. Answer Key: Q1: E (Slide 46) Q2: D (Slide 45) Q3: E (Slides 29/35/39) Q4: A (Slides 35/36)...
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This note was uploaded on 01/04/2011 for the course BIO 314 taught by Professor Erster,s during the Spring '08 term at SUNY Stony Brook.

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BIO 314 Spring Exam - includes A PDGF/PDGF-R B EGF HER2 C Sis/PDGF-R D A& B E All of the Above Q4 Herceptin A Is a monoclonal antibody targeting

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