Fall 2009 BIO 314 MT3 exam and answers for BB

Fall 2009 BIO 314 MT3 exam and answers for BB - *Fall 2009...

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*Fall 2009 BIO 314 Midterm 3 Choose the best answer for all 30 questions. Be sure to copy your answer to your scantron. MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question. 1) Which of the following statements is true? A) Telomerase -/- mice have an aging phenotype, telomerase-/- human cells have a tumor phenotype. B) Mice have very long telomeres, so even though they shorten over the lifespan of the animal, they never get short enough to trigger breakage-fusion-bridge. C) A cell with dicentric chromosomes has probably escaped crisis and entered senescence. D) Telomeres don't shorten in normal mice because telomerase is expressed in all somatic cells of adult mice. 2) In the mouse skin carcinogenesis model A) It required a second "painting" with a promoter to form a carcinoma. B) A carcinoma formed only if the initiator and promoter were applied at the same time. C) A papilloma that forms will regress unless paintings with initiator or promoter occur. D) It required a second "painting" with an initiator to form a papilloma. 3) Nonsteroidal anti-inflammatory drugs reduce cancer incidence because they A) stimulate prostaglandin synthesis B) inhibit NFkB expression C) induce TNF-alpha expression D) promote IkB degradation E) none of the above are correct 4) In normal differentiated adult somatic cells A) telomeres shorten everytime the cell replicates its DNA, and eventually the cell undergoes apoptosis. B) telomeres shorten everytime the cell replicates its DNA, and eventually the cell upregulates telomerase. C) telomeres shorten everytime the cell replicates its DNA, and eventually the cell enters crisis. D) telomeres shorten everytime the cell replicates its DNA, and eventually the cell enters senescence. 5) Why does dysfunctional adipose tissue increase cancer incidence and cancer mortality? A) Dysfunctional adipose tissue can have activated proliferative and survival signaling via Ras, NFkB and IL-6 pathways. B) Dysfunctional adipocytes secrete elevated levels of myc protein. C) Many cancers metastasize to dysfunctional adipose tissue. D) The oxidation of fat in dysfunctional adipose tissue releases reactive oxygen species that mutagenize adipocyte DNA. E) In dysfunctional adipose tissue, the response to hypoxia is repressed. 1
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6) FACS analyses of metastatic cancers showed that, in a given tumor, A) the cells are not all equally tumorigenic. B) the cells are heterogeneous in size. C) the cells may have varying degrees of gene amplification and deletion. D) some cells have withdrawn from the cell cycle, while others are proliferative. E) most of the cells no longer have anaphase bridges.
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This note was uploaded on 01/04/2011 for the course BIO 314 taught by Professor Erster,s during the Spring '08 term at SUNY Stony Brook.

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Fall 2009 BIO 314 MT3 exam and answers for BB - *Fall 2009...

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