Practice_Midterm_4_–_FALL_2009

Practice_Midterm_4_–_FALL_2009 - Practice...

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Practice Midterm 4 – FALL 2009 1.Cell genomes are attacked by A.UV, which forms covalent bonds between adjacent purines, resulting in purine dimers. B. Biochemical processes that result in deamination and transversions from C to T C.X-rays that result in double stranded breaks D. Alkylating agents that methylate nitrogenous bases and result in extra bonds between the deoxy- ribose and the base. E. All of the above 2.Benzopyrendiolepoxide(BPDE) A. is processed by cells and ends up as benzopyrene B. causes C to change to T C. causes G to change to T D. affects Ras and p53 genes E. B and D F. C and D 3.How are damaged/mutated genomes repaired or treated? A. RNA polymerase has proof-reading exonucleolytic activity that allows it to go back and degrade the synthesized strand and resynthesize the proper strand B. MMR enzymes detect nicks in strands of newly synthesized DNA, remove them, and repair the strands. C. In a tumor with high levels of MGMT, treatment of the tumor consists of chemotherapy. D. MGMT is able to detect changes in DNA sequences, such as from C to T, and is able to convert them back to the correct base E. None of the above 4. A _______ is a change in DNA sequence from __:__; a _________ is a change in DNA sequence
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Practice_Midterm_4_–_FALL_2009 - Practice...

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