Handout - Lecture 4 - Neurodevelopment

Handout - Lecture 4 - Neurodevelopment - Click to edit...

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Unformatted text preview: Click to edit Master subtitle style 1/5/11 NEURODEVELOPMEN T 1/5/11 5 Stages of Neural Development Childhood Neural Development Adult Neurogenesis & Neuroplasticity Lecture Outline 1/5/11 When does neural development begin? When does it end? The human brain is plastic continuously grows and changes according to: Genetic programming Experience in the environment Main Ideas: Click to edit Master subtitle style 1/5/11 Neural Development 1/5/11 1) Induction of the Neural Plate 2) Neural Proliferation 3) Migration and Aggregation 4) Axon Growth & Synapse Formation 5) Neuron Death & Synapse Rearrangement 5 Phases of Neural 1/5/11 Neural Plate patch of tissue Ý develops into nervous system Recognizable by day 18 (after conception) 1. Induction of Neural Plate 1/5/11 1. Induction of Neural Plate Neural plate changes: 21 days folds to form neural groove 24 days Lips of neural groove fuse to form neural tube Inside becomes cerebral ventricles and spinal canal 1/5/11 1/5/11 Cells in the neural plate change from being totipotent to multipotent Stem cells meet 2 criteria Unlimited capacity for self-renewal Can develop into different types of mature cells Increasingly specific: 1. Induction of Neural Plate 1/5/11 1) Induction of the neural plate 2) Neural proliferation 3) Migration and Aggregation 4) Axon Growth & Synapse Formation 5) Neuron Death & Synapse Rearrangement 5 Phases of Neural 1/5/11 Proliferation increase in number by cell division Sequence of proliferation determines characteristics of developing brain (e.g. patterns of folding, shape, etc.) At this point in development, most proliferation 2. Neural Proliferation 1/5/11 1) Induction of the neural plate 2) Neural proliferation 3) Migration and Aggregation 4) Axon Growth & Synapse Formation 5) Neuron Death & Synapse Rearrangement 5 Phases of Neural 1/5/11 Move from the ventricular zone to the target location in 2 directions : Radial migration...
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This note was uploaded on 01/05/2011 for the course PSY 10994 taught by Professor Ericdonny during the Spring '08 term at Pittsburgh.

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Handout - Lecture 4 - Neurodevelopment - Click to edit...

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