Handout - Lecture 14 - Mood disorders

Handout - Lecture 14 - Mood disorders - Affective disorders...

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Click to edit Master subtitle style 1/5/11 Affective disorders (we will focus mostly on depression)
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1/5/11 Symptoms of depression Loss of interest Irritability
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1/5/11 Affective Disorders Unipolar depression Just experience depression (no mania) Women are 2-3x as likely to experience it 16% attempt suicide Bipolar disorder Alternating periods of depression and mania
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1/5/11 Affective Disorders Genetics concordance rate for monozygotic twins is ~ 69%; ~ 13% for fraternal twins Even stronger for bipolar Many different genes have been linked to affective disorders Genes on chromosomes 1, 4, 9, 10, 11, 12, 13, 14, 17, 18, 20, 21, 22 and X (you do NOT need to memorize these)
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1/5/11 Theories of depression Monoamine theory
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1/5/11 Theories of depression Monoamine theory – due to underactivity at serotonergic and noradrenergic synapses Consistent with genetic evidence Low levels of 5-HIAA (serotonin metabolite) is associated with depression and suicide Post-mortem data suggest that depressed people have more 5-HT and NE receptors
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This note was uploaded on 01/05/2011 for the course PSY 10994 taught by Professor Ericdonny during the Spring '08 term at Pittsburgh.

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Handout - Lecture 14 - Mood disorders - Affective disorders...

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