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Handout%20-%20Lecture%204%20-%20Neurodevelopment

Handout%20-%20Lecture%204%20-%20Neurodevelopment - 5 Stages...

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9/15/2008 1 5 Stages of Neural Development Childhood Neural Development Adult Neurogenesis & Neuroplasticity When does neural development begin? When does it end? The human brain is plastic continuously grows and changes according to: Genetic programming Experience in the environment
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9/15/2008 2 1) Induction of the Neural Plate 2) Neural Proliferation 3) Migration and Aggregation 4) Axon Growth & Synapse Formation 5) Neuron Death & Synapse Rearrangement Neural Plate patch of tissue develops into nervous system Recognizable by day 18 (after conception)
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9/15/2008 3 Neural plate changes: Cells in the neural plate change from being totipotent to multipotent Stem cells meet 2 criteria Unlimited capacity for self-renewal Can develop into different types of mature cells Increasingly specific: Cells . . . nervous system cells . . . glial cells or neurons . . . specific subtypes of glia and neurons . . . . .
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9/15/2008 4 1) Induction of the neural plate 2) Neural proliferation 3) Migration and Aggregation 4) Axon Growth & Synapse Formation 5) Neuron Death & Synapse Rearrangement Proliferation increase in number by cell division Sequence of proliferation determines characteristics of developing brain (e.g. patterns of folding, shape, etc.) At this point in development, most proliferation occurs in the ventricular zone 1) Induction of the neural plate 2) Neural proliferation 3) Migration and Aggregation 4) Axon Growth & Synapse Formation 5) Neuron Death & Synapse Rearrangement
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9/15/2008 5 Move from the ventricular zone to the target location in 2 directions : Radial migration - Tangential migration Most cells use both types of migration to get to target location Migration occurs by 2
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