Handout%20-%20Lecture%205%20-%20Neuromethods

Handout%20-%20Lecture%205%20-%20Neuromethods - 9/15/2008...

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9/15/2008 1 Neuromethods Lesioning or Ablation Electrolytic Chemical Aspiration Knife Damage to the brain Stroke victims Head trauma Genetic abnormalities Neurodegeneration
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9/15/2008 2 Stimulation Stimulation Pass current into area Generates action potentials Example Stimulating pre-central gyrus does what? Movement Recording electrical activity Single unit recording Multiple unit recording Recording neurochemical activity Microdialysis
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9/15/2008 3 Pharmacological methods Using drugs to understand the brain Important issues Affinity ability to bind receptor Efficacy ability to produce the biological response of the target Specificity the degree to which the ligand targets the receptor of interest and not other receptors agonist: affinity and maximum efficacy antagonist : affinity without efficacy partial agonist: affinity and partial efficacy Neuroimaging Computerized axial tomography aka, CT or CAT scan Contrast dye X-rays taken a full 180 degrees around the head and pooled to create a structural image of the brain Examples of use Identify and locate aneurysm Detect enlarged ventricles (hydrocephalus) Neuroimaging
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This note was uploaded on 01/05/2011 for the course PSY 10994 taught by Professor Ericdonny during the Spring '08 term at Pittsburgh.

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Handout%20-%20Lecture%205%20-%20Neuromethods - 9/15/2008...

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