ch12 - Chapter 12 Enzyme Kinetics Inhibition and Control...

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Chapter 12: Enzyme Kinetics, Inhibition and Control Matching A) isozymes B) substrate binding C) rate constant D) Ping Pong E) bimolecular F) ES complex G) large K D H) mixed inhibition I) unimolecular J) [A] 2 K) competitive inhibition L) phosphorylation M) small K D 1. The 2A B reaction is ______. Ans: E Level of Difficulty: Easy Section: 12.1.A Learning objective: Reaction Kinetics 2. The rate of the reaction 2A B is dependent on ______. Ans: J Level of Difficulty: Easy Section: 12.1.A Learning objective: Reaction Kinetics 3. A zero-order reaction's rate is dependent on the ______. Ans: C Level of Difficulty: Easy Section: 12.1.B Learning objective: Reaction Kinetics
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4. A two-substrate enzymatic reaction in which one product is produced before the second substrate binds to the enzyme has a ______ mechanism. Ans: D Level of Difficulty: Easy Section: 12.1.D Learning objective: Reaction Kinetics 5. The type of enzyme inhibition in which V max is unaffected is ______. Ans: K Level of Difficulty: Moderate Section: 12.2.A Learning objective: Enzyme Inhibition 6. In uncompetitive inhibition, the inhibitor binds only to the ______. Ans: F Level of Difficulty: Moderate Section: 12.2.B Learning objective: Enzyme Inhibition 7. A common type of covalent modification of regulatory enzymes involves ______ of serine residues. Ans: L Level of Difficulty: Moderate Section: 12.3.B Learning objective: Control of Enzyme Activity 8. A lead compound for a new drug should bind to its target protein with a very ______. Ans: M Level of Difficulty: Moderate Section: 12.4.A Learning objective: Drug Design 9. Different enzymes that catalyze the same reaction are known as ______. Ans: A
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Level of Difficulty: Easy Section: 12.3.B Learning objective: Control of Enzyme Activity 10. In ______, the inhibitor binds to a site involved in both substrate binding and catalysis. Ans: H Level of Difficulty: Easy Section: 12.2.C Learning objective: Enzyme Inhibition Multiple Choice 11. A lead compound would be most promising if it had: A) K I = 4.7 x 10 5 M. B) K I = 1.5 x 10 8 M. C) K I = 1.5 x 10 -8 M. D) K I = 4.7 x 10 -5 M. E) K M = 4.7 x 10 5 M. Ans: C Level of Difficulty: Moderate Section: 12.4.A Learning objective: Drug Design
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