Homework 6_optional_ ANSWER KEY

Homework 6_optional_ ANSWER KEY - 1. You are asked by your...

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You are asked by your boss at OEHHA to estimate a cancer potency factor from the following data using the benchmark dose approach. The data are from a study by NTP where the investigators dosed female rats orally with ochratoxin, a mold metabolite contaminant of grains. The study was conducted with a full lifetime exposure. The incidence of tumors is shown in the table below. Data from NTP report on ochratoxin. Renal Tubular Cell Tumors in Female F344 Rats Treated With OTA by Oral Gavage (NTP, 1989). Lifetime Average Dose 1 (mg/kg-day) Tumor Incidence 2 Adenoma Carcinoma Adenoma and Carcinoma Combined Female 0 0/49 0/49 0/49 0.0149 0/49 0/49 0/49 0.0495 1/50 1/50 2/50 0.149 5/49* 3/49 8/49*** 3 Results of pairwise comparison relative to control, by Fisher’s exact test; * p<0.05, ** p<0.01, *** p<0.005, **** p<0.001. You run the Benchmark Dose software using the cancer multistage model, and get the following output: Goodness of Fit Chi^2 = 0.51 d.f. = 2 P-value = 0.7760 Benchmark Dose Computation Specified effect = 0.1 Risk Type = Extra risk Confidence level = 0.95 BMD = 0.108169 BMDL = 0.0707276
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This note was uploaded on 01/05/2011 for the course ETX 63002 taught by Professor Melaniemarty during the Fall '10 term at UC Davis.

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Homework 6_optional_ ANSWER KEY - 1. You are asked by your...

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