Quiz 3 ANSWER KEY_Word03

Quiz 3 ANSWER KEY_Word03 - ETX 135 Quiz 3 Answer Key 1....

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ETX 135 Quiz 3 Answer Key 1. Review the following graph and data output and answer the following questions (30 points). Female mice were exposed to perchloroethylene and the following results were reported by the National Toxicology Program (1986). Concentration (ppm) Incidence of Hepatocellular Carcinoma 0 1/48 100 13/50 200 36/50 The data were input into the USEPA Benchmark Dose program with the following output. BMDS MODEL RUN Benchmark Dose Computation Specified effect = 0.1 Risk Type = Extra risk Confidence level = 0.95 BMD = 58.8867 BMDL = 30.6206 BMDU = 67.4858 Taken together, (30.6206, 67.4858) is a 90% two-sided confidence interval for the BMD a. What do the terms BMD and BMDL mean? What is the difference between the two? (4 points) BMD stands for benchmark dose, the dose calculated by modeling actual data that produces an extra risk of 10% (in this example) above background for tumor formation. BMDL is the 95% lower bound of the benchmark dose for the specified response rate. The BMDL takes into account uncertainty of
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This note was uploaded on 01/05/2011 for the course ETX 63002 taught by Professor Melaniemarty during the Fall '10 term at UC Davis.

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Quiz 3 ANSWER KEY_Word03 - ETX 135 Quiz 3 Answer Key 1....

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