week 3 short answer answer

week 3 short answer answer - Biology 112 Unicellular life...

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Biology 112: Unicellular life Drs. Kion, Spiegelman, Taylor Two proteins, A and B, are discovered and upon studying their structures it is found that three amino acids are clustered together inside each of them (that is, a cluster is found in the interior of A and B). The three amino acids are tryptophan, phenylalanine, and threonine (the side chains of each are shown below). Phe Trp HN Thr H 3 C OH Some melting temperatures experiments are performed where the phenylalanine or the tryptophan are replaced with alanine in both of the proteins. The resulting data is shown below. Protein Change Melting Temperature No change (normal) 71 o C Phe changed to Ala 69 o C A Trp changed to Ala 69 o C No change (normal) 71 o C Phe changed to Ala 69 o C B Trp changed to Ala 66 o C Note that denaturation temperatures can be determined very accurately so a difference of 2-3 o C is considered to represent a significant change in the protein structure. Based on the above data, what conclusions can you make about the
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This note was uploaded on 01/06/2011 for the course BIO 112 taught by Professor Taylor during the Fall '09 term at UBC.

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week 3 short answer answer - Biology 112 Unicellular life...

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