week 3 slides

week 3 slides - sequence information into parts that can do...

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1 2 µ m Structure of nucleic acids The backbone of each strand of DNA is a polymer of riboses linked with Phosphates the phosphates like the #5 carbon of one phosphate to the #3 Carbon of the next. So there is an orientation 5’-3’, or 3’-5’ 5’ carbon 3’ carbon 1’ 2’ 4’ Other base pairs are possible, but only A-T and G-C have the same geometry Interactions between bases in the DNA 1. Hydrogen bonds between bases of the two DNA strands. 2. Adjacent bases interact within the same strand. These “stacking interactions” are what holds DNA together. End on view
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2 Minor groove Major groove Major Groove side Minor Groove side Amino acids interactions with the groups in the major groove of DNA Neidle, Stephen. Nucleic Acid Structure and Recognition . Oxford University Press, 2002, p. 90. www.sdsc.edu/pb/edu/pharm201/02/02.ppt O = H H O = H H
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3 Thinking about RNA Reading the instructions. Turning stored
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Unformatted text preview: sequence information into parts that can do something. In a typical bacterial cell there is @ 30 times more RNA than DNA. Two classes of RNA: Stable and unstable Stable: RNA in ribosomes: 3 different molecules 23S, 16S, 5S (rRNA) 90% of RNA in cell transfer RNA (tRNA) @60 5% of RNA Unstable messenger RNA (mRNA) 5% of RNA Thinking about RNA Stable: RNA in ribosomes: 3 different molecules 23S, 16S, 5S (rRNA) 23S @ 2100 b 16S @ 1500 b 5S @100 b Thousands of ribosomes/cell transfer RNA (tRNA) @60 types many copies of each The ribosome (contains proteins too) Base pairing in 16S ribosomal RNA (rRNA) About 1500 bases long with base-paired regions (stems), and unpaired loops and bulges. Double stranded regions would be helical. 5’ 3’ A tRNA on the same scale tRNA. Highly folded RNA about 100 nucleotides long Note the helical region...
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