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lecture28 - 7.03 Lecture 28-30 Lecture 28 Polymorphisms in...

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7.03 Lecture 28-30 11/17/03, 11/19/03, 11/21/03 1 Lecture 28: Polymorphisms in Human DNA Sequences •SNPs •SSRs
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7.03 Lecture 28-30 11/17/03, 11/19/03, 11/21/03 2 The methods of genetic analysis that you have been learning are applicable to mammals — even to humans. However, we need to combine these genetic principles with an understanding of the physical realities of the human genome. To genetics we will add genomics. Eukaryotic Genes and Genomes = DNA content of a gamete (sperm or egg) genome = DNA content of a complete haploid set of chromosomes H. sapiens M. musculus D. melanogaster C. elegans S. cerevisiae E. coli genes/ haploid year sequence completed DNA content/ haploid(Mb) cM Chromosomes Species 1 16 6 4 20 23 N/A 4000 300 280 1700 3300 5 12 100 180 3000 3000 1997 1997 1998 2000 4,200 5,800 19,000 14,000 30,000? 30,000? Mb = megabase = 1 million base-pairs of DNA Kb = kilobase = 1 thousand base-pairs of DNA Note: cM = centi Morgan = 1% recombination 2002 draft 2001 draft 2005 finished? 2003 finished
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7.03 Lecture 28-30 11/17/03, 11/19/03, 11/21/03 3 3000 3300 H. sapiens 3000 1700 M. musculus 180 280 D. melanogaster 100 300 C. elegans 12 4000 S. cerevisiae 5 N/A E. coli true breeding strains? design crosses? generation time DNA content/ haploid (Mb) cM Species 30 min 90 min 4 d 2 wk 3 mo 20 yr yes yes yes yes yes yes yes yes yes yes no no Let's add some columns to a table we constructed several lectures back: You might add a column indicating the number of offspring per adult. What are the implications of
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