Lecture 9 - Recognition -Immune System

Lecture 9 - Recognition -Immune System -...

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Proteins-Protein Interactions     of the Immune System
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Concepts to learn today Structure of the antibody molecule – IgG The immunoglobulin fold Hypervariable loops form the antigen-binding sites Structure of the major histocompatibility complex – MHC The MHC fold and peptide-binding sites Structure of the T-cell receptor T-cell receptor recognize antigen ONLY when it is bound in the peptide-binding site of the MHC
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Self vs. Not Self Immune system recognizes, destroys and remembers foreign parasites while ignoring the host’s cells and proteins Recognizes foreign molecules = Antigen B cells release Immunoglobulins to circulation T cells have T cell Receptor that recognizes when presented on MHC class 1 protein
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Immunoglobulin Molecule - IgG Heterotetramer 2 Light chains +2 Heavy chains Linked by 4 disulfide bonds Hinge region of HC gives flexibilbity Ig fold is distorted β barrel Each LC contains 2 Ig folds
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This note was uploaded on 01/07/2011 for the course BIBC BIBC 100 taught by Professor Buehler during the Fall '09 term at UCSD.

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Lecture 9 - Recognition -Immune System -...

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