Lectures 12 - 14 - Membranes_biochemistry6e_ch12_Short_

Lectures 12 - 14 - Membranes_biochemistry6e_ch12_Short_ -...

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Unformatted text preview: THE LIPID BILAYER • Fundamental structure of cell membranes • Of the same rank of importance as the DNA double helix and the α-helix and β-sheets of proteins • A thin film (40 Α thick) with a hydrophobic core ( ε ~2) separating two aqueous compartments ( ε ~80) THE LIPID BILAYER QUESTIONS • How membrane proteins fold? • How charged and polar molecules go through lipid bilayers? Membrane Proteins Concepts to learn today • The interplay between the bilayer hydrophobic – interfacial environment and the protein which dictate the membrane protein fold • How membrane proteins provide a solution to the question of how charged and polar molecules traverse bilayers Bacteriorhodopsin • 7 transmembrane α-helices • Binds Retinaldehyde via a Schiff Base , a covalent bond between K216 and retinal. • Molecular switch which transforms light energy into a H + electrochemical gradient, i.e., a H + pump • It catalyzes vectorial H...
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This note was uploaded on 01/07/2011 for the course BIBC BIBC 100 taught by Professor Buehler during the Fall '09 term at UCSD.

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Lectures 12 - 14 - Membranes_biochemistry6e_ch12_Short_ -...

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