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Unformatted text preview: Click to edit Master subtitle style 1/9/11 Gluconeogenesis and the pentose phosphate 1/9/11 • Which of the following compounds cannot serve as the starting material for the synthesis of glucose via gluconeogenesis? • Fructose • l -ketoglutarate • acetate • oxaloacetate 1/9/11 1/9/11 • Which of the following compounds cannot serve as the starting material for the synthesis of glucose via gluconeogenesis? • Fructose • l -ketoglutarate • acetate • oxaloacetate 1/9/11 • An increase in the cytosolic concentration of which of the following will increase flux through the pentose phosphate pathway? • glucose • NADP+ • NADPH • Ribulose-5-phosphate 1/9/11 • Section 16.5: • “Regulation of the pathway is simply by product demand; removal of NADPH regenerates NADP and thus pulls the pathway forward.” • ANSWER: NADP+ 1/9/11 • Pyruvate carboxylase could be expected to be inhibited by: • glucose • acetyl CoA • ATP • ADP • Fructose-2,6-bisphosphate 1/9/11 • Glucose: NOT in the mitochondria • Acetyl CoA: Activates PC • ATP: PC is ATP-dependent • F-2,6-bp: Not in mitochondria • ANSWER: ADP 1/9/11 • Oxaloacetate produced from pyruvate carboxylase: • Is reduced to malate. • Continues gluconeogenesis in the mitochondria. • Diffuses out of the mitochondria to continue gluconeogenesis. • Is paired with biotin to be pumped 1/9/11 1/9/11 • Oxaloacetate produced from pyruvate carboxylase: • Is reduced to malate. • Continues gluconeogenesis in the mitochondria. • Diffuses out of the mitochondria to continue gluconeogenesis. • Is paired with biotin to be pumped 1/9/11 • The pentose phosphate pathway is responsible for generating factors and precursors for which of the following: • nucleotides • amino acids • reducing equivalents • all of the above 1/9/11 1/9/11 • The pentose phosphate pathway is responsible for generating factors and precursors for which of the following: • nucleotides • amino acids • reducing equivalents • all of the above 1/9/11 • Which of the following is not an effector of fructose-1, 6- bisphosphatase • Citrate • Fructose-2,6-bisphosphate • ATP • AMP • ADP 1/9/11 • Which of the following is not an effector of fructose-1, 6- bisphosphatase • Citrate • Fructose-2,6-bisphosphate • ATP • AMP • ADP 1/9/11 Pentose Phosphate Pathway (7) Is the reaction Glucose + ATP Glucose-6- Phosphate the committing step for glycolysis? a. Yes, because it has a large negative G Δ b. No, because Glucose-6-Phosphate can enter into other cycles such as the pentose phosphate pathway. c. Yes, because the enzyme hexokinase is a highly regulated enzyme. d. No, there is no committed step for glycolysis. 1/9/11 • The committing step will be the step that will commit glucose to being metabolized....
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This note was uploaded on 01/08/2011 for the course BIS 103 taught by Professor Abel during the Winter '08 term at UC Davis.

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Homeanswers_7-11 - Click to edit Master subtitle style...

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