Fiehn BIS103 lecture 3_fall 2010

Fiehn BIS103 lecture 3_fall 2010 - Overview of metabolic...

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1 Overview of metabolic pathways Sterols PPP Glycolysis three stages: investment, C-C cleavage, harvest Activation energy investment cleavage Oxidation energy gain Glucose C6 2x C3 2x Pyruvate C3 Δ G
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2 Glycolysis three stages: investment, C-C cleavage, harvest phosphorylation cleavage oxidation 1 2 3 5 4 6 7 8 9 10 Glycolysis stage 1: substrate activation, isomerization 1 2 3
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3 Mg 2+ Glycolysis stage 1 : activation by phosphorylation (‘Kinase’) 1 Glycolysis stage 1 : mechanism. Hexokinase induced fit binding site glucose causes conformational change
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4 hexokinase: - high affinity - inhibited by Glc-6-P - low substrate specificity (e.g. fructose, mannos) glucokinase (hexokinase D): - in liver and β -cells - lower affinity - not inhibited by Glc-6P - high substrate specificity Glycolysis stage 1: kinase substrate specificity glucose enzyme activity Glycolysis stage 1: phosphoglucoisomerase works near equilibrium 2
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5 Mg 2+ Glycolysis stage 1: phosphofructokinase activates for C-C cleavage 3 Glycolysis stage 2: C-C bond cleavage, isomerization 5 4
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